European champions Liverpool need a point at Austrian side Red Bull Salzburg on Tuesday to be sure of a place in the Champions League last 16.
Liverpool are top of Group E and will guarantee finishing in that position with a win.
Salzburg, who lost 4-3 at Anfield in October, need to win and hope Napoli are beaten by Belgian side Genk.
“Everybody knows it’s a final and we’re prepared – Salzburg has to win against us,” said Liverpool boss Jurgen Klopp.
“We are not a typical Champions League winner, we’re still ambitious like crazy, we will go for everything and run for our lives.
“It’s not that I expect us to go through, I expect us to play the best game we can play.”
Reds midfielder Adam Lallana misses out through injury, but central defender Dejan Lovren and midfielder Georginio Wijnaldum are both in the 19-man squad.
Liverpool, who beat Tottenham 2-0 in last season’s final in June, could have qualified with a game to spare if they had beaten Napoli in their last Champions League match, but the Italian side held them to a 1-1 draw at Anfield.
If the Reds lose to Salzburg, they will need Genk to take points off Napoli or Klopp’s side will drop down to the Europa League.